Supporting Online Material for Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors
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Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors.
Glutamate receptors of the AMPA-subtype (AMPARs), together with the transmembrane AMPAR regulatory proteins (TARPs), mediate fast excitatory synaptic transmission in the mammalian brain. Here, we show by proteomic analysis that the majority of AMPARs in the rat brain are coassembled with two members of the cornichon family of transmembrane proteins, rather than with the TARPs. Coassembly with c...
متن کاملJochen Schwenk , as Auxiliary Subunits of AMPA Receptors Functional Proteomics Identify Cornichon
www.sciencemag.org (this information is current as of March 12, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/323/5919/1313 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/323/5919/1313/DC1 can be foun...
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Cornichon-2 and cornichon-3 (CNIH-2/-3) are AMPA receptor (AMPAR) binding proteins that promote receptor trafficking and markedly slow AMPAR deactivation in heterologous cells, but their role in neurons is unclear. Using CNIH-2 and CNIH-3 conditional knockout mice, we find a profound reduction of AMPAR synaptic transmission in the hippocampus. This deficit is due to the selective loss of surfac...
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